Phosoplex and Gout - Gout: New Treatments and Recommendations for Prevention
Gout commonly presents together with a sudden onset of redness, swelling and excruciating pain of the great toe joint during the night. Gout is a painful joint condition brought on by hyperuricemia (high levels of uric acid in the blood) resulting in the actual precipitation of needle-like crystals in the joints. The prevalence of gout has been steadily increasing over the past two decades is now estimated to be 1-2% of the U.S. population. Gout is more common in men, but in recent years, the incidence of gout has doubled in women (1,2). The common causes of gout are diet, overproduction of uric acid and renal disease. Common risk factors include family history, male gender, a high protein diet, heavy alcohol consumption consumption, high blood pressure, kidney disease, metabolic syndrome, diuretic use and obesity. Hyperuricemia has been suspected to increase the risk of heart disease by increasing inflammatory factors that damage arteries (3).
Arthritis Rheum. 2010 Jan Arch Intern Med. 2009;169( :502- Curr Rheumatol Rep. 2010 Apr;12( :118-24 Pharmacotherapy. 2010 Jun;30( :594-
The Most Effective Prevention of Gout is the Modification of Diet and LifestyleSpecific foods and beverages, such as red meat and alcohol, can result in a severe gout attack. Weight problems increases the risk of gout as well as other conditions which increase the risk of gout, such as high blood pressure and also metabolic syndrome. Weight reduction and also daily exercise are both appropriate protective remedies for gout. Other recommendations include limiting intake of sugary beverages and foods with added sugar, consuming whole grains, nuts, beans, fruits, greens, moderate amounts of lean white meats and low fat dairy products and oily fish ( . You may want to talk to your doctor about adding a vitamin c supplement or increasing your coffee intake. It may take some time to comprehend the matter on Gout Prevention that we have listed here. However, it is only through it's complete comprehension would you get the right picture of Gout Prevention.
Treatment Varies Regarding Acute and Chronic GoutFor acute gout flares, the standard treatment is a course of anti-inflammatory medications, steroid injections and/or joint aspiration. Allopurinol is commonly used for treatment of chronic gout and prevention of acute gout attacks. Febuxostat is a new treatment recently approved by the Fda. In long term studies over a 5-year period, febuxostat has been shown to reduce uric acid levels as well as substantially lower or perhaps eliminate acute gout episodes ( . A study last year in the Archives of Internal Medicine showed 500 mg of Vitamin c each day reduced the incidence of gout by 15% ( . Researchers at the Arthritis Research Centre of Canada in Vancouver found long-term coffee consumption is associated with a lower incidence of gout. Those who drank four + cups of coffee per day had the least risk of developing gout ( . The authors did not recommend starting to drink coffee for those people who do not previously drink coffee.
The relationship between heart disease and gout has been thought to be more coincidental than causative, right up until recently. Recent research suggests uric acid may be a causative factor in heart disease. Uric acid activates the immune response and the inflammatory process. This reaction can be seen in an acute gout flare involving a painful, red, hot, swollen great toe joint. Uric acid is both an antioxidant and a pro-oxidant. This means that even though uric acid may quench free radicals and reduce oxidative cell damage, it also increases mediators which affect blood vessels and increase the risk of heart disease ( .